The Shrine of the Immaculate Conception. Fodor's has a neat story:
During the Battle of Atlanta, Thomas O'Reilly, the church's pastor, persuaded Union forces to spare his church and several others around the city. That 1848 structure was then replaced by this much grander building, whose cornerstone was laid in 1869.
It's a little sad that, while the pastor managed to save the church from war, it was replaced twenty years later anyway. (Incidentally, it burned in the 80s and had to be significantly restored.)

Frankly, it doesn't look impressive to me. I originally thought this church, that I saw earlier on the other side of the block, must've been the famous one.